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KMID : 0361120060200010001
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Korean Journal of Transplantation
2006 Volume.20 No. 1 p.1 ~ p.13
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Prevention of Allograft Rejection by Immune Tolerance
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이종수
권병석/조홍래
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Abstract
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The development of immunosuprressants has had a significant contribution to inhibition of acute allograft rejection.However, long-term graft survival has not been realized by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune olerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using three different approaches; mixed hematopoietic chimerism, costimulatory blockade, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection. (J Korean Soc Transplant 2006;20:1-13)
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KEYWORD
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Transplantation tolerance, Mixed hematopoietic chimerism, Costimulatory blockade, Regulatory T cells
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